Dr Ko

Chien-Chih Ke,

Assistant Professor

  Academic Degree

    Ph.D., Institute of Clinical Medicine, National Yang Ming University, Taiwan


    Radiochemistry(Including Laboratory)

     Molecular Imaging

    Special Topics in Biomedical Molecular Imaging

     Special Topics in Radiopharmaceuticals

  Research Interests


    Radiation Oncology

    Stem Cell Biology

    Molecular Imaging


    Lab: (CS-620)

    TEL: +886-7-312-1101 ext 2356-24


  1. Liu B, Luo C, Zheng Z, Xia Z, Zhang Q, Ke CC, Liu RS, Zhao Y. Shengui Sansheng San extraction is an angiogenic switch via regulations of AKT/mTOR, ERK1/2 and Notch1 signal pathways after ischemic stroke. Phytomedicine. 2018, 44: 20-31
  2. Hsieh YJ, Wu LC, Ke CC, Chang CW, Kuo JW, Huang WS, Chen FD, Yang BH, Tai HT, Chen SC, Liu RS. Effects of the acute and chronic ethanol intoxication on acetate metabolism and kinetics in the rat brain. Alcoholism: Clinical and Experimental Research. 2018;42(2):329-337
  3. Ke CC, He ZM, Hsieh YJ, Huang CW, Li JJ, Hwu L, Chen YA, Yang BH, Chang CW, Huang WS, Liu RS. Quantitative Measurement of the Thyroid Uptake Function of Mouse by Cerenkov Luminescence Imaging. Scientific Reports. 2017;7(1):5717
  4. Liu NW, Ke CC*, Zhao Y, Chen YA, Chan KC, Tan DT, Lee JS, Chen YY, Hsu TW, Hsieh YJ, Yang BH, Chang CW, Huang WS, Liu RS. Evolutional Characterization of Photochemically Induced Stroke in Rats: A Multimodality Imaging and Molecular Biological Study. Translational Stroke Research. 2017;8(3), 244-256 (*co-first author)
  5. Zhang Q, Chen ZW, Zhao YH, Liu BW, Liu NW, Ke CC, Tan HM. Bone Marrow Stromal Cells Combined with Sodium Ferulate and n-Butylidenephthalide Promote the Effect of Therapeutic Angiogenesis via Advancing Astrocyte-Derived Trophic Factors after Ischemic Stroke. Cell transplantation. 2017;26(2):229-242
  6. Zhang Q, Zhao Y, Xu Y, Chen Z, Liu NW, Ke CC, Liu B, Wu W. Sodium Ferulate and n-butylidenephthalate Combined with Bone Marrow Stromal Cells (BMSCs) Improve the Therapeutic Effects of Angiogenesis and Neurogenesis after Rat Focal Cerebral Ischemia. Journal of Translational Medicine. 2016;14(1):223
  7. Yang YC, Chin YT, Hsieh MT, Lai HY, Ke CC, Crawford DR, Lee OK, Fu E, Mousa SA, Grasso P, Liu LF, Chang HY, Tang HY, Lin HY, Davis PJ. Novel leptin OB3 peptide-induced signaling and progression in thyroid cancers: Comparison with leptin. Oncotarget. 2016, 7(19):27641-54
  8. Zhao Y, Zhang Q, Chen Z, Liu NW, Ke CC, Xu Y, Wu W. Simvastatin combined with bone marrow stromal cells treatment activates astrocytes to ameliorate neurological function after ischemic stroke in rats. Turkish Journal of Biology 2016, 40(2):519-528
  9. Hsieh YJ, Hwu L, Ke CC, Huang AL, Chen FD, Wu SJ, Chen SC, Zhao YH, Liu RS. Demonstration of Tightly Radiation-Controlled Molecular Switch Based on CArG Repeats by In Vivo Molecular Imaging. Mol Imaging Biol. 2015, (6):802-10
  10. Hsieh YJ, Hwu L, Ke CC, Yeh HH, Lin CF, Chen FD, Wang HE, Lin KP, Chen RC, Liu RS. Rational Design of a Triple Reporter Gene for Multimodality Molecular Imaging. Biomed Res Int. 2014, 2014:605358.
  11. Hsieh YJ, Hwu L, Chen YC, Ke CC, Chen FD, Wang HE, Lin KP, Yeh HH, Chang CW, Liu RS. P21-driven multi-fusion gene system for evaluating the efficacy of histone deacetylase inhibitors by in vivo molecular imaging and for transcription targeting therapy of cancer mediated by histone deacetylase inhibitor. J Nucl Med. 2014, 55(4):678-85.
  12. Ke CC, Liu RS, Suetsugu A, Kimura H, Ho JH, Lee OK, Hoffman RM. Real-Time Imaging of the Interaction of Mesenchymal Stromal Cells and Mammary Cancer Cells In Vitro and In Vivo. PLoS ONE. 2013, 8(7): e69658.
  13. Ke CC, Liu RS, Lee CH, Yang AH, Tseng LM, Tsai YF, Chi CW, Ho JH, Lee OK. CD133-Expressing Thyroid Cancer Cells Are in an Undifferentiated State, Radioresistant and Survive Radioiodide Therapy. European Journal of Nuclear Medicine and Molecular Imaging. 2013, 40(1):61-71
  14. Yang AH, Chau YP, Lee CH, Chen JY, Chen JY, Ke CC, Liu RS. The Influence of Neural Cell Adhesion Molecule Isoform 140 on the Metastasis of Thyroid Carcinoma. Clinical & Experimental Metastasis. 2012, 30(3):299-307
  15. Hsieh YJ, Chen FD, Ke CC, Wang HE, Huang CJ, Hou MF, Lin KP, Gelovani JG, Liu RS. The EIIAPA Chimeric Promoter for Tumor Specific Gene Therapy of Hepatoma. Mol Imaging Biol. 2012, 14(4):452-61.
  16. Ke CC, Hsieh YJ, Hwu L, Wang FH, Chen FD, Chu LS, Lee OK, Chi CW, Lee CH, Liu RS. Evaluation of Lentiviral-Mediated Expression of Sodium Iodide Symporter in Anaplastic Thyroid Cancer and The Efficacy of In Vivo Imaging and Therapy. Journal of Oncology 2011, 2011:178967.
  17. Liu RS, Hsieh YJ, Ke CC, Chen FD, Hwu L, Wang FH, Hwang JJ, Chi CW, Lee CH, Yeh SH. Specific Activation of Sodium Iodide Symporter Gene in Hepatoma Using Alpha-Fetoprotein Promoter Combined with Hepatitis B Virus Enhancer (EIIAPA). Anticancer Research. 2009, 29(1):211-221.
  18. Hsieh YJ, Ke CC*, Liu RS, Wang FH, Tang KT, Chi CW, Chen FD, Lee CH. Radioiodide Imaging and Treatment of ARO Cancer Xenograft in a Mouse Model after Expression of Human Sodium Iodide Symporter. Anticancer Research. 2007, 27(4B):2515-2522. (*co-first author)
  19. Hsieh YJ, Liu RS, Hwu L, Ke CC, Wang FH, Wang HE, Chen FD. Cre/loxP System Controlled by Specific Promoter for Radiation-Mediated Gene Therapy of Hepatoma. Anticancer Research. 2007, 27(3B):1571-1579.
  20. Hsieh YJ, Chen FD, Wang FH, Ke CC, Wang HE, Liu RS. Molecular Switch of Cre/loxP for Radiation Modulated Gene Therapy on Hepatoma. Nuclear Instruments and Methods in Physics Research Section A 2007, 571(1):453-456

Book Chapter

  1. Ke CC, Liu RS. Chapter 32 - Lentiviral-Encoded Sodium Iodide Symporter- Mediated Cancer Gene Therapy. Gene Therapy of Cancer (Third Edition). San Diego: Academic Press; 2014: 463-78.

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