Yu-Chang Tyan,

Professor and Chair

    Ph.D., Institute of Biomedical Engineering, Chung Yuan Christian University, Taiwan

    Biomedical Engineering

    General Chemistry

    Special Topics in Radiation Technology

    Biomedical Engineering

    Proteomics

    Biomedical Mass Spectroscopy

    Lab：CS-620A

    TEL: +886-7-312-1101 ext 2357-20

    E-mail:yctyan at kmu.edu.tw

1. Hsin-Chieh Wu, Te-Yen Su, Tsuey-Lin Tsai, Shiang-Bin Jong, Ming-Hui Yang, Yu-Chang Tyan*. Rapid determination of technetium-99 by automatic solid phase extraction and inductively coupled plasma mass spectrometry. RSC Advances, 4, 39226-39230. (SCI, 35/148, CHEMISTRY, MULTIDISCIPLINARY).
2. Wen-Hung Wang, Yu-Chang Tyan (Co-First), Zong-Shiow Chen, Ching-Gong Lin, Ming-Hui Yang, Shyng-Shiou Yuan, Wan-Chi Tsai*. Evaluation of the Antioxidant Activity and Antiproliferative Effect of the Jaboticaba (Myrciaria cauliflora) Seed Extracts in Oral Carcinoma Cells. Biomed Res Int., 2014,Article ID 185946, 7 pages. (SCI, 53/165, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
3. Sung-Pin Tseng, Wan-Chi Tsai, Chih-Yuan Liang, Yin-Shiou Lin, Jun-Wei Huang, Chung-Yu Chang, Yu-Chang Tyan, Po-Liang Lu*. The Contribution of Antibiotic Resistance Mechanisms in Clinical Burkholderia cepacia Complex Isolates: An Emphasis on Efflux Pump Activity. PLOS ONE , 9(6) e104986-. (SCI, 8/55, MULTIDISCIPLINARY SCIENCES).
4. Ming-Hui Yang, Shyng-Shiou Yuan, Yi-Ling Chen, Pei-Yu Chu, Shiang-Bin Jong, Ying-Fong Huang, Chi-Yu Lu, Yi-Shan Lu, Po-Chiao Lin, Yu-Chang Tyan*. Mass Spectrometry in Clinical Diagnosis: A Preliminary Application in Tumor Cellular Proteomics for Biomarker Discovery. J Anal Bioanal Tech, 2014, S2. 1-13.
5. Ming-Hui Yang, Shyng-Shiou Yuan, Ying-Fong Huang, Po-Chiao Lin, Chi-Yu Lu, Tze-Wen Chung, Yu-Chang Tyan*. A Proteomic View to Characterize the Effect of Chitosan Nanoparticle to Hepatic Cells: Is Chitosan Nanoparticle an Enhancer of PI3K/AKT1/mTOR Pathway?. BioMed Research International, Volume 2014, Article ID 789591, 9 pages. (SCI, 50/160, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
6. Ming-Hui Yang, S.-S.F. Yuan, Shiang-Bin Jong, Chi Yu Lu, Wan-Chi Tsai, Wen-Cheng Chen, Po-Chiao Lin, Pei-Wen Chiang, Tze-Wen Chung and Yu-Chang Tyan*. Characterization of silk fibroin modified surface: a proteomic view of cellular response proteins induced by biomaterials. BioMed Research International, 2014, 1-13. (SCI, 65/158, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
7. Chun-Chi Chen, Basker Rajagopal, Xuan Yu Liu, Kuan Lin Chen, Yu-Chang Tyan, FuI Lin, Po-Chiao Lin*. A Mild Removal of Fmoc Group Using Sodium Azide. Amino Acids, 46(2):367-374. (SCI, 86/290, BIOCHEMISTRY & MOLECULAR BIOLOGY).
8. Yun-Ju Chen, Yu-Jen Cheng, Amos C Hung, Yang-Chang Wu, Ming-Feng Hou, Yu-Chang Tyan*, Shyng-Shiou Yuan*. The synthetic flavonoid WYC02-9 inhibits cervical cancer migration/invasion and angiogenesis via MAPK14 signaling. Gynecologic Oncology, 131, 734–743. (SCI, 5/78, OBSTETRICS & GYNECOLOGY).
9. Rong-Chun Chen, Lea-Yea Chuang, Wei-Lung Tseng, Yu-Chang Tyan, Chi-Yu Lu*. Determination of phosphoserine/threonine by nanoUPLCMS/MS coupled with micro-scale labeling. Anal Biochem, 443, 187-196. (SCI, 26/75, CHEMISTRY, ANALYTICAL).
10. Ya-Wen Chuang, Chien-Chin Hsu, Ying-Fong Huang*, Hsiu-Fen Lin, Chin-Chuan Chang, Chia-Yang Lin, Yu-Chang Tyan*. Brain Perfusion SPECT in Patients with Behcet’s Disease. Journal of Neuroradiology, 40, 288-293. (SCI, 85/116, RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING).
11. Ming-Hui Yang, Hung Su, Yi-Ling Chen, Chi-Yu Lu, Wan-Chi Tsai, Yu-Chang Tyan*, Yu-Chun Liu, Ching-Wen Kuo, Yu-Ching Hsu. Utilized mass spectrometry-based protein profiling system to identify potential biomarkers of hepatocellular carcinoma. Biomarkers and Genomic Medicine, 5, 96-99.
12. Ming-Hui Yang, Yi-Ling Chen, Chi-Yu Lu, Wan-Chi Tsai, Yu-Chang Tyan*, Yu-Chun Liu, Ching-Wen Kuo, Yu-Ching Hsu. Is NAP an additional neuroprotector in Alzheimer's disease? Biomarkers and Genomic Medicine, 5, 103-106.
13. Yi-Shan Lu, Ming-Hui Yang, Chi-Yu Lu, Wan-Chi Tsai, Yu-Chang Tyan*, Yu-Ching Hsu, Ching-Wen Kuo, Yu-Chun Liu. The proteomic study of the Ultraviolet-C radiation effect for Vigna radiata. Journal of Agriculture and Forestry, 62, 65-78.
14. Yi-Shan Lu, Ming-Hui Yang, Chi-Yu Lu, Chia-Chieh Chen, Ying-Fong Huang, Yu-Ching Hsu, Ching-Wen Kuo, Yu-Chun Liu, Shiang-Bin Jong*, Yu-Chang Tyan*. The proteomic study of the gamma ray irradiation effect for Vigna radiata. Radiological Technology, 44, 1-10.
15. Yi-Syuan Hong, Ing-Jun Chen, Ming-Hui Yang, Ying-Fong Huang, Shiang-Bin Jong*, Yu-Chang Tyan*, Yu-Ching Hsu, Ching-Wen Kuo, Yu-Chun Liu. The study of optimal reaction condition for KMUP-1 labeling radioactive iodine. Radiological Technology , 44, 11-17.
16. Chia-Ling Ko, Wen-Cheng Chen*, Jian-Chih Chen, Ying-Hui Wang, Chi-Jen Shih, Yu-Chang Tyan, Chun-Cheng Hung, Jen-Chyan Wang. Properties of osteoconductive biomaterials: calcium phosphate cement with different ratios of platelet-rich plasma as identifiers. Materials Science and Engineering C, 33 (2013) 3537–3544. (SCI, 10/25, MATERIALS SCIENCE, BIOMATERIALS).
17. Ming-Hui Yang, Hsien-Yi Wang, Chi Yu Lu, Wan-Chi Tsai, Po-Chiao Lin, Shih-Bin Su, Yu-Chang Tyan* (2013, May). Proteomic profiling for peritoneal dialysate: Differential protein expression in diabetes mellitus. BioMed Research International, Volume 2013, Article ID 642964, 15 pages. (SCI, 65/158, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
18. Yu-Chang Tyan*, Ming-Hui Yang, Tze-Wen Chung, Chi-Yu Lu, Wan-Chi Tsai, Shiang-Bin Jong. Assessing human urinary proteome using a mass spectrometry-based profiling system combined with magnetic nanoparticles. Clinica Chimica Acta, 420; 54-61. (SCI, 6/32, MEDICAL LABORATORY TECHNOLOGY).
19. Yu-Chang Tyan*, Shiang-Bin Jong, Ming-Hui Yang, Tsung-Lin Wu, Tze-Wen Chung, Pao-Chi Liao, Chia-Yang Lin, Ying-Fong Huang. Utilizing isotope dilution-matrix-assisted laser desorption ionization-time of flight mass spectrometry as a reference procedure for the radioimmunoassay of serum thyroxine. Clinica Chimica Acta, 420; 99-103. (SCI, 6/32, MEDICAL LABORATORY TECHNOLOGY).
20. Yu-Chang Tyan, Shih-Bin Su, Sing-Sing Ting, Hsien-Yi Wang, Pao-Chi Liao*. A comparative proteomics analysis of peritoneal dialysate before and after the occurrence of peritonitis episode by mass spectrometry. Clinica Chimica Acta, 420; 34-44. (SCI, 6/32, MEDICAL LABORATORY TECHNOLOGY).
21. Ming-Hui Yang, Adnan Dibas, Yu-Chang Tyan*. Changes in retinal aquaporin-9 (AQP9) expression in glaucoma. Biosci Rep, 33 (2) 379-385. (SCI, 121/181, CELL BIOLOGY).
22. Tze-Wen Chung*, Yu-Chang Tyan, Rong-Ho Lee, Chia-Wei Ho. Determining early adhesion of cells on polysaccharides/PCL surfaces by a quartz crystal microbalance.. J Mater Sci Mater Med., 23:3067–3073. (SCI, 21/72, ENGINEERING, BIOMEDICAL).
23. Ming-Hui Yang, Shiang-Bin Jong, Chi-Yu Lu, Yu-Fen Lin, Pei-Wen Chiang, Yu-Chang Tyan*, Tze-Wen Chung*. Assessing the responses of cellular proteins induced by hyaluronic acid-modified surfaces utilizing mass spectrometry-based profiling system: over-expression of CD36, CD44, CDK9, and PP2A. Analyst, 137(21):4921-4933. (SCI, 8/75, CHEMISTRY, NALYTICAL).
24. Ming-Hui Yang, Yuan-Han Yang, Chi-Yu Lu, Shiang-Bin Jong, Li-Jhen Chen, Yu-Fen Lin, Shyh-Jong Wu, Pei-Yu Chu, Tze-Wen Chung, Yu-Chang Tyan*. Activity-dependent neuroprotector homeobox protein: a candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease. Journal of Proteomics, 75: 3617-3629. (SCI, 15/75, BIOCHEMICAL RESEARCH METHODS).
25. Yu-Fen Lin, Ming-Hui Yang, Yuan-Han Yang, Wen-Cheng Chen, Chi-Yu Lu, Chien-Fang Peng, Shiang-Bin Jong, Li-Jhen Chen, Shyh-Jong Wu, Pei-Yu Chu, Tze-Wen Chung, Yu-Chang Tyan*. Activity-dependent neuroprotector homeobox protein level in Alzheimer's disease in Taiwanese. Genomic Medicine, Biomarkers, and Health Sciences, 4, 48-50.
26. Yu-Chang Tyan*, Ming-Hui Yang, Sharon Chia-Ju Chen, Shiang-Bin Jong, Wen-Cheng Chen, Yuan-Han Yang, Tze-Wen Chung, Pao-Chi Liao. Characterization of urinary proteome from Blackfoot disease endemic areas - The over-expression of ADAM28 in bladder transitional cell carcinomas. Rapid Communications in Mass Spectrometry, 25, 2851-2862. (SCI, 13/43, SPECTROSCOPY).
27. Ming-Hui Yang, Pei-Yu Chu, Sharon Chia-Ju Chen, Tze-Wen Chung, Wen-Cheng Chen, Lia-Beng Tan, Wei-Chih Kan, Hsien-Yi Wang, Shih-Bin Su, Yu-Chang Tyan*. Characterization of ADAM28 as a biomarker of bladder transitional cell carcinoma by urinary proteome analysis. Biochemical and Biophysical Research Communications, 411, 714-720. (SCI, 39/72, BIOPHYSICS).
28. Ming-Hui Yang, Raghu R. Krishnamoorthy, Shiang-Bin Jong, Pei-Yu Chu,Yuan-Han Yang, Wen-Cheng Chen, Sharon Chia-Ju Chen, Adnan Dibas, Thomas Yorio, Tze-Wen Chung, Yu-Chang Tyan*.Protein profiling of human non-pigmented ciliary epithelium cell secretome – the differentiation factors characterization for retinal ganglion cell-line. J Biomed Biotechnol, 2011, (901329) 1-28. (SCI, 65/158, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
29. Tze-Wen Chung*, Thitima Limpanichpakdee, Ming-Hui Yang, Yu-Chang Tyan. An electrode of quartz crystal microbalance (QCM) decorated with CNT/chitosan/ fibronectin (FN) for investigating early adhesion and deforming morphology of rat mesenchymal stem cells (rMSCs). Carbohydrate Polymers, 85(4), 726-732. (SCI, 4/71, CHEMISTRY, APPLIED).
30. Yu-Chang Tyan*, Ming-Hui Yang, Tze-Wen Chung, Wen-Cheng Chen, Ming-Chen Wang, Yi-Ling Chen, Shu-Ling Huang, Ying-Fong Huang, Shiang-Bin Jong*. Characterization of surface modification on self-assembled monolayer-based piezoelectric crystal immunosensor for the quantification of serum <alpha>-fetoprotein. Journal of Materials Science: Materials in Medicine, 22, 1383-1391. (SCI, 21/72, ENGINEERING, BIOMEDICA).
31. Yuan-Han Yang, Chiou-Lian Lai, Yu-Chang Tyan, Mei-Chuan Chou, Ling-Chun Wang, Ming-Hui Yang, Ching-Kuan Liu*. Angiotensin-converting enzyme gene and plasma protein level in Alzheimer’s disease in Taiwanese. Age and Ageing, 40, 238-242. (SCI, 13/45, GERIATRICS & GERONTOLOGY).
32. Huan-Yao Wang, Li-Hua Lo, Yu-Chang Tyan, Hung-Chun Chen, Ming-Hui Yang, Tzu-Yin Chen, Hay-Yan J. Wang*, Jentaie Shiea*. The study of the distribution of melamine in rat renal tissues by imaging mass spectrometry. Anal. Methods, 2, 1974-1981. (SCI, 49/128, FOOD SCIENCE & TECHNOLOGY).
33. Yi-Shan Lu, Ying-Fong Huang, Pei-Wen Chiang, Ting-Yin Liu, Yi-Ling Chen, Ming-Hui Yang, Pao-Chi Liao, Shiang-Bin Jong*, Yu-Chang Tyan*. Using isotope dilution combined with matrix-assisted laser desorption ionizationtime of flight mass spectrometry as a reference method for the radioimmunoassay of 3,5,3’-triiodothyronine. Annals of Nuclear Medicine and Science, 23, 189-194.
34. Lifeng Peng, Eugene A. Kapp, David Fenyo, Min-Seok Kwon, Pu Jiang, Songfeng Wu, Ying Jiang, Marie-Isabel Aguilar, Nikhat Ahmed, Mark S. Baker, Zongwei Cai, Yu-Ju Chen, Phan Van Chi, Maxey C. M. Chung, Fuchu He, Alice C. L. Len, Pao-Chi Liao, Kazuyuki Nakamura, Sai Ming Ngai, Young-Ki Paik, Tai-Long Pan, Terence C. W. Poon, Ghasem Hosseini Salekdeh, Richard J. Simpson, Ravi Sirdeshmukh, Chantragan Srisomsap, Jisnuson Svasti, Yu-Chang Tyan, Florian S. Dreyer, Danyl McLauchlan, Pisana Rawson and T. William Jordan*. The Asia Oceania Human Proteome Organisation Membrane Proteomics Initiative. Preparation and characterization of the carbonate-washed membrane standard. Proteomics, 10, 4142–4148. (SCI, 14/72, BIOCHEMICAL RESEARCH METHODS).
35. Tze-Wen Chung*, Yu-Chang Tyan, Jean-Dean Yang. PCP copolymers arafted with RGD enhance the rates of RGD-PCP micelles internalized into cells. Journal of Microencapsulation, 27(6): 514-520. (SCI, 25/71, CHEMISTRY, APPLIED).
36. Yu-Chang Tyan, Hsin-Chieh Wu, Kung-Tien Liu, Hung-I Tsai, Tsuey-Lin Tsai, Ming-Hui Yang, Shiang-Bin Jong*. Determination of Technetium-99 in environmental samples by flow injection-ICP-MS. Chemistry, 68, 225-233.
37. Lia-Beng Tan, Kow-Tong Chen, Yu-Chang Tyan, Pao-Chi Liao, How-Ran Guo*. Identification of urine PLK2 as a marker of bladder tumors by proteomic analysis. World J Urol, 28:117-122. (SCI, 17/73, UROLOGY & NEPHROLOGY).
38. Jen-Chyan Wang, Chia-Ling Ko, Chun-Cheng Hung, Yu-Chang Tyan, Chern-Hsiung Lai, Wen-Cheng Chen*, Chih-Kuang Wang. Deriving fast setting properties of tetracalcium phosphate/dicalcium phosphate anhydrous bone cement with nanocrystallites on the reactant surfaces. Journal of Dentistry, 38, 158-165. (SCI, 7/83, DENTISTRY, ORAL SURGERY & MEDICINE).
39. Tze-Wen Chung*, Shyr-Yi Lin, Der-Zen Liu, Yu-Chang Tyan, Juin-Sen Yang. Sustained release of 5-FU from Poloxamer gels interpenetrated by crosslinking chitosan network. Int J Pharm, 382(1-2):39-44. (SCI, 198/261, PHARMACOLOGY & PHARMACY).
40. Pao-Chi Liao, Yu-Chang Tyan*, Chung-Yao Wang, Jing-Fang Hsu, Tse-Chuan Chou, Hsin-Yi Lin. Assessing the binding selectivity of molecularly imprinted polymer artificial antibodies by mass spectrometry-based profiling system. J Biomed Mater Res, 91A: 597–604. (SCI, 13/79, ENGINEERING, BIOMEDICAL).
41. Shang-Kwei Wang*, Cheng-Hui Hu, Miao-Chan Lu, Chang-Yih Duh, Pao-Chi Liao, Yu-Chang Tyan. Novel virus-associated proteins encoded by UL112-113 of human cytomegalovirus. J Gen Virol., 90(Pt 12):2840-8. (SCI, 44/160, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
42. Ming-Hui Yang, Li-Hua Lo, Yi-Hsuan Chen, Jentaie Shiea*, Pei-Chang Wu, Yu-Chang Tyan, Yuh-Jyh Jong. Study of human neutrophil peptides in saliva by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry, 23: 3220–3226. (SCI, 19/73, Chemistry analytical).
43. Shiang-Bin Jong, Shu-Ling Huang, Chang-Shiun Lin, Ming-Hui Yang, Yi-Ling Chen, Ying-Fong Huang, Jentaie Shiea, Ming-Chen Wang, Yu-Chang Tyan*. Evaluation the Effectiveness of 125 I Anti-AFP Monoclonal Antibody on QCM Utilizing Radioactive Measurement. CHEMISTRY , Vol. 67, No. 3, pp. 299-307.
44. Shu-Ling Huang, Chang-Shiun Lin, Yi-Shan Lu, Shiang-Bin Jong, Ming-Hui Yang, Hsiu-Yu Chang, Yu-Chang Tyan*. α-fetoprotein analysis in human serum through quartz crystal microbalance. IFMBE Proceedings, 25, 116-119. (EI).
45. Yu-Chang Tyan*, Ming-Hui Yang*, Shiang-Bin Jong, Chih-Kuang Wang, Jentaie Shiea. Melamine contamination. Anal Bioanal Chem, 395:729–735. (SCI, 9/75, CHEMISTRY, ANALYTICAL).
46. Ming-Hui Yang, Yu-Chang Tyan*. Proteomic approaches for urine biomarker discovery in bladder cancer. Translational Bioinformatics: Bioinformatics of Human Proteomics. Translational Bioinformatics: Bioinformatics of Human Proteomics. Feb, 2013: Volume 3, 2013, pp 309-329.
47. Ming-Hui Yang, Shiang-Bin Jong, Tze-Wen Chung, Ying-Fong Huang, Yu-Chang Tyan*. Quartz crystal microbalance in clinical application. Biosensors for Health, Environment and Biosecurity. Biosensors for Health, Environment and Biosecurity / Book 2. Jul, 2011: Chapter 11, 257-272.