Dr Tyan


Yu-Chang Tyan,


  Academic Degree

    Ph.D., Institute of Biomedical Engineering, Chung Yuan Christian University, Taiwan


    Biomedical Engineering

    General Chemistry

    Special Topics in Radiation Technology

  Research Interests/Introduction

    Biomedical Engineering


    Biomedical Mass Spectroscopy



    TEL: +886-7-312-1101 ext 2357-20

    E-mail:yctyan at

  1. Hsin-Chieh Wu, Te-Yen Su, Tsuey-Lin Tsai, Shiang-Bin Jong, Ming-Hui Yang, Yu-Chang Tyan*. Rapid determination of technetium-99 by automatic solid phase extraction and inductively coupled plasma mass spectrometry. RSC Advances, 4, 39226-39230. (SCI, 35/148, CHEMISTRY, MULTIDISCIPLINARY).
  2. Wen-Hung Wang, Yu-Chang Tyan (Co-First), Zong-Shiow Chen, Ching-Gong Lin, Ming-Hui Yang, Shyng-Shiou Yuan, Wan-Chi Tsai*. Evaluation of the Antioxidant Activity and Antiproliferative Effect of the Jaboticaba (Myrciaria cauliflora) Seed Extracts in Oral Carcinoma Cells. Biomed Res Int., 2014,Article ID 185946, 7 pages. (SCI, 53/165, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
  3. Sung-Pin Tseng, Wan-Chi Tsai, Chih-Yuan Liang, Yin-Shiou Lin, Jun-Wei Huang, Chung-Yu Chang, Yu-Chang Tyan, Po-Liang Lu*. The Contribution of Antibiotic Resistance Mechanisms in Clinical Burkholderia cepacia Complex Isolates: An Emphasis on Efflux Pump Activity. PLOS ONE , 9(6) e104986-. (SCI, 8/55, MULTIDISCIPLINARY SCIENCES).
  4. Ming-Hui Yang, Shyng-Shiou Yuan, Yi-Ling Chen, Pei-Yu Chu, Shiang-Bin Jong, Ying-Fong Huang, Chi-Yu Lu, Yi-Shan Lu, Po-Chiao Lin, Yu-Chang Tyan*. Mass Spectrometry in Clinical Diagnosis: A Preliminary Application in Tumor Cellular Proteomics for Biomarker Discovery. J Anal Bioanal Tech, 2014, S2. 1-13.
  5. Ming-Hui Yang, Shyng-Shiou Yuan, Ying-Fong Huang, Po-Chiao Lin, Chi-Yu Lu, Tze-Wen Chung, Yu-Chang Tyan*. A Proteomic View to Characterize the Effect of Chitosan Nanoparticle to Hepatic Cells: Is Chitosan Nanoparticle an Enhancer of PI3K/AKT1/mTOR Pathway?. BioMed Research International, Volume 2014, Article ID 789591, 9 pages. (SCI, 50/160, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
  6. Ming-Hui Yang, S.-S.F. Yuan, Shiang-Bin Jong, Chi Yu Lu, Wan-Chi Tsai, Wen-Cheng Chen, Po-Chiao Lin, Pei-Wen Chiang, Tze-Wen Chung and Yu-Chang Tyan*. Characterization of silk fibroin modified surface: a proteomic view of cellular response proteins induced by biomaterials. BioMed Research International, 2014, 1-13. (SCI, 65/158, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
  7. Chun-Chi Chen, Basker Rajagopal, Xuan Yu Liu, Kuan Lin Chen, Yu-Chang Tyan, FuI Lin, Po-Chiao Lin*. A Mild Removal of Fmoc Group Using Sodium Azide. Amino Acids, 46(2):367-374. (SCI, 86/290, BIOCHEMISTRY & MOLECULAR BIOLOGY).
  8. Yun-Ju Chen, Yu-Jen Cheng, Amos C Hung, Yang-Chang Wu, Ming-Feng Hou, Yu-Chang Tyan*, Shyng-Shiou Yuan*. The synthetic flavonoid WYC02-9 inhibits cervical cancer migration/invasion and angiogenesis via MAPK14 signaling. Gynecologic Oncology, 131, 734–743. (SCI, 5/78, OBSTETRICS & GYNECOLOGY).
  9. Rong-Chun Chen, Lea-Yea Chuang, Wei-Lung Tseng, Yu-Chang Tyan, Chi-Yu Lu*. Determination of phosphoserine/threonine by nanoUPLCMS/MS coupled with micro-scale labeling. Anal Biochem, 443, 187-196. (SCI, 26/75, CHEMISTRY, ANALYTICAL).
  10. Ya-Wen Chuang, Chien-Chin Hsu, Ying-Fong Huang*, Hsiu-Fen Lin, Chin-Chuan Chang, Chia-Yang Lin, Yu-Chang Tyan*. Brain Perfusion SPECT in Patients with Behcet’s Disease. Journal of Neuroradiology, 40, 288-293. (SCI, 85/116, RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING).
  11. Ming-Hui Yang, Hung Su, Yi-Ling Chen, Chi-Yu Lu, Wan-Chi Tsai, Yu-Chang Tyan*, Yu-Chun Liu, Ching-Wen Kuo, Yu-Ching Hsu. Utilized mass spectrometry-based protein profiling system to identify potential biomarkers of hepatocellular carcinoma. Biomarkers and Genomic Medicine, 5, 96-99.
  12. Ming-Hui Yang, Yi-Ling Chen, Chi-Yu Lu, Wan-Chi Tsai, Yu-Chang Tyan*, Yu-Chun Liu, Ching-Wen Kuo, Yu-Ching Hsu. Is NAP an additional neuroprotector in Alzheimer's disease? Biomarkers and Genomic Medicine, 5, 103-106.
  13. Yi-Shan Lu, Ming-Hui Yang, Chi-Yu Lu, Wan-Chi Tsai, Yu-Chang Tyan*, Yu-Ching Hsu, Ching-Wen Kuo, Yu-Chun Liu. The proteomic study of the Ultraviolet-C radiation effect for Vigna radiata. Journal of Agriculture and Forestry, 62, 65-78.
  14. Yi-Shan Lu, Ming-Hui Yang, Chi-Yu Lu, Chia-Chieh Chen, Ying-Fong Huang, Yu-Ching Hsu, Ching-Wen Kuo, Yu-Chun Liu, Shiang-Bin Jong*, Yu-Chang Tyan*. The proteomic study of the gamma ray irradiation effect for Vigna radiata. Radiological Technology, 44, 1-10.
  15. Yi-Syuan Hong, Ing-Jun Chen, Ming-Hui Yang, Ying-Fong Huang, Shiang-Bin Jong*, Yu-Chang Tyan*, Yu-Ching Hsu, Ching-Wen Kuo, Yu-Chun Liu. The study of optimal reaction condition for KMUP-1 labeling radioactive iodine. Radiological Technology , 44, 11-17.
  16. Chia-Ling Ko, Wen-Cheng Chen*, Jian-Chih Chen, Ying-Hui Wang, Chi-Jen Shih, Yu-Chang Tyan, Chun-Cheng Hung, Jen-Chyan Wang. Properties of osteoconductive biomaterials: calcium phosphate cement with different ratios of platelet-rich plasma as identifiers. Materials Science and Engineering C, 33 (2013) 3537–3544. (SCI, 10/25, MATERIALS SCIENCE, BIOMATERIALS).
  17. Ming-Hui Yang, Hsien-Yi Wang, Chi Yu Lu, Wan-Chi Tsai, Po-Chiao Lin, Shih-Bin Su, Yu-Chang Tyan* (2013, May). Proteomic profiling for peritoneal dialysate: Differential protein expression in diabetes mellitus. BioMed Research International, Volume 2013, Article ID 642964, 15 pages. (SCI, 65/158, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
  18. Yu-Chang Tyan*, Ming-Hui Yang, Tze-Wen Chung, Chi-Yu Lu, Wan-Chi Tsai, Shiang-Bin Jong. Assessing human urinary proteome using a mass spectrometry-based profiling system combined with magnetic nanoparticles. Clinica Chimica Acta, 420; 54-61. (SCI, 6/32, MEDICAL LABORATORY TECHNOLOGY).
  19. Yu-Chang Tyan*, Shiang-Bin Jong, Ming-Hui Yang, Tsung-Lin Wu, Tze-Wen Chung, Pao-Chi Liao, Chia-Yang Lin, Ying-Fong Huang. Utilizing isotope dilution-matrix-assisted laser desorption ionization-time of flight mass spectrometry as a reference procedure for the radioimmunoassay of serum thyroxine. Clinica Chimica Acta, 420; 99-103. (SCI, 6/32, MEDICAL LABORATORY TECHNOLOGY).
  20. Yu-Chang Tyan, Shih-Bin Su, Sing-Sing Ting, Hsien-Yi Wang, Pao-Chi Liao*. A comparative proteomics analysis of peritoneal dialysate before and after the occurrence of peritonitis episode by mass spectrometry. Clinica Chimica Acta, 420; 34-44. (SCI, 6/32, MEDICAL LABORATORY TECHNOLOGY).
  21. Ming-Hui Yang, Adnan Dibas, Yu-Chang Tyan*. Changes in retinal aquaporin-9 (AQP9) expression in glaucoma. Biosci Rep, 33 (2) 379-385. (SCI, 121/181, CELL BIOLOGY).
  22. Tze-Wen Chung*, Yu-Chang Tyan, Rong-Ho Lee, Chia-Wei Ho. Determining early adhesion of cells on polysaccharides/PCL surfaces by a quartz crystal microbalance.. J Mater Sci Mater Med., 23:3067–3073. (SCI, 21/72, ENGINEERING, BIOMEDICAL).
  23. Ming-Hui Yang, Shiang-Bin Jong, Chi-Yu Lu, Yu-Fen Lin, Pei-Wen Chiang, Yu-Chang Tyan*, Tze-Wen Chung*. Assessing the responses of cellular proteins induced by hyaluronic acid-modified surfaces utilizing mass spectrometry-based profiling system: over-expression of CD36, CD44, CDK9, and PP2A. Analyst, 137(21):4921-4933. (SCI, 8/75, CHEMISTRY, NALYTICAL).
  24. Ming-Hui Yang, Yuan-Han Yang, Chi-Yu Lu, Shiang-Bin Jong, Li-Jhen Chen, Yu-Fen Lin, Shyh-Jong Wu, Pei-Yu Chu, Tze-Wen Chung, Yu-Chang Tyan*. Activity-dependent neuroprotector homeobox protein: a candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease. Journal of Proteomics, 75: 3617-3629. (SCI, 15/75, BIOCHEMICAL RESEARCH METHODS).
  25. Yu-Fen Lin, Ming-Hui Yang, Yuan-Han Yang, Wen-Cheng Chen, Chi-Yu Lu, Chien-Fang Peng, Shiang-Bin Jong, Li-Jhen Chen, Shyh-Jong Wu, Pei-Yu Chu, Tze-Wen Chung, Yu-Chang Tyan*. Activity-dependent neuroprotector homeobox protein level in Alzheimer's disease in Taiwanese. Genomic Medicine, Biomarkers, and Health Sciences, 4, 48-50.
  26. Yu-Chang Tyan*, Ming-Hui Yang, Sharon Chia-Ju Chen, Shiang-Bin Jong, Wen-Cheng Chen, Yuan-Han Yang, Tze-Wen Chung, Pao-Chi Liao. Characterization of urinary proteome from Blackfoot disease endemic areas - The over-expression of ADAM28 in bladder transitional cell carcinomas. Rapid Communications in Mass Spectrometry, 25, 2851-2862. (SCI, 13/43, SPECTROSCOPY).
  27. Ming-Hui Yang, Pei-Yu Chu, Sharon Chia-Ju Chen, Tze-Wen Chung, Wen-Cheng Chen, Lia-Beng Tan, Wei-Chih Kan, Hsien-Yi Wang, Shih-Bin Su, Yu-Chang Tyan*. Characterization of ADAM28 as a biomarker of bladder transitional cell carcinoma by urinary proteome analysis. Biochemical and Biophysical Research Communications, 411, 714-720. (SCI, 39/72, BIOPHYSICS).
  28. Ming-Hui Yang, Raghu R. Krishnamoorthy, Shiang-Bin Jong, Pei-Yu Chu,Yuan-Han Yang, Wen-Cheng Chen, Sharon Chia-Ju Chen, Adnan Dibas, Thomas Yorio, Tze-Wen Chung, Yu-Chang Tyan*.Protein profiling of human non-pigmented ciliary epithelium cell secretome – the differentiation factors characterization for retinal ganglion cell-line. J Biomed Biotechnol, 2011, (901329) 1-28. (SCI, 65/158, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
  29. Tze-Wen Chung*, Thitima Limpanichpakdee, Ming-Hui Yang, Yu-Chang Tyan. An electrode of quartz crystal microbalance (QCM) decorated with CNT/chitosan/ fibronectin (FN) for investigating early adhesion and deforming morphology of rat mesenchymal stem cells (rMSCs). Carbohydrate Polymers, 85(4), 726-732. (SCI, 4/71, CHEMISTRY, APPLIED).
  30. Yu-Chang Tyan*, Ming-Hui Yang, Tze-Wen Chung, Wen-Cheng Chen, Ming-Chen Wang, Yi-Ling Chen, Shu-Ling Huang, Ying-Fong Huang, Shiang-Bin Jong*. Characterization of surface modification on self-assembled monolayer-based piezoelectric crystal immunosensor for the quantification of serum <alpha>-fetoprotein. Journal of Materials Science: Materials in Medicine, 22, 1383-1391. (SCI, 21/72, ENGINEERING, BIOMEDICA).
  31. Yuan-Han Yang, Chiou-Lian Lai, Yu-Chang Tyan, Mei-Chuan Chou, Ling-Chun Wang, Ming-Hui Yang, Ching-Kuan Liu*. Angiotensin-converting enzyme gene and plasma protein level in Alzheimer’s disease in Taiwanese. Age and Ageing, 40, 238-242. (SCI, 13/45, GERIATRICS & GERONTOLOGY).
  32. Huan-Yao Wang, Li-Hua Lo, Yu-Chang Tyan, Hung-Chun Chen, Ming-Hui Yang, Tzu-Yin Chen, Hay-Yan J. Wang*, Jentaie Shiea*. The study of the distribution of melamine in rat renal tissues by imaging mass spectrometry. Anal. Methods, 2, 1974-1981. (SCI, 49/128, FOOD SCIENCE & TECHNOLOGY).
  33. Yi-Shan Lu, Ying-Fong Huang, Pei-Wen Chiang, Ting-Yin Liu, Yi-Ling Chen, Ming-Hui Yang, Pao-Chi Liao, Shiang-Bin Jong*, Yu-Chang Tyan*. Using isotope dilution combined with matrix-assisted laser desorption ionizationtime of flight mass spectrometry as a reference method for the radioimmunoassay of 3,5,3’-triiodothyronine. Annals of Nuclear Medicine and Science, 23, 189-194.
  34. Lifeng Peng, Eugene A. Kapp, David Fenyo, Min-Seok Kwon, Pu Jiang, Songfeng Wu, Ying Jiang, Marie-Isabel Aguilar, Nikhat Ahmed, Mark S. Baker, Zongwei Cai, Yu-Ju Chen, Phan Van Chi, Maxey C. M. Chung, Fuchu He, Alice C. L. Len, Pao-Chi Liao, Kazuyuki Nakamura, Sai Ming Ngai, Young-Ki Paik, Tai-Long Pan, Terence C. W. Poon, Ghasem Hosseini Salekdeh, Richard J. Simpson, Ravi Sirdeshmukh, Chantragan Srisomsap, Jisnuson Svasti, Yu-Chang Tyan, Florian S. Dreyer, Danyl McLauchlan, Pisana Rawson and T. William Jordan*. The Asia Oceania Human Proteome Organisation Membrane Proteomics Initiative. Preparation and characterization of the carbonate-washed membrane standard. Proteomics, 10, 4142–4148. (SCI, 14/72, BIOCHEMICAL RESEARCH METHODS).
  35. Tze-Wen Chung*, Yu-Chang Tyan, Jean-Dean Yang. PCP copolymers arafted with RGD enhance the rates of RGD-PCP micelles internalized into cells. Journal of Microencapsulation, 27(6): 514-520. (SCI, 25/71, CHEMISTRY, APPLIED).
  36. Yu-Chang Tyan, Hsin-Chieh Wu, Kung-Tien Liu, Hung-I Tsai, Tsuey-Lin Tsai, Ming-Hui Yang, Shiang-Bin Jong*. Determination of Technetium-99 in environmental samples by flow injection-ICP-MS. Chemistry, 68, 225-233.
  37. Lia-Beng Tan, Kow-Tong Chen, Yu-Chang Tyan, Pao-Chi Liao, How-Ran Guo*. Identification of urine PLK2 as a marker of bladder tumors by proteomic analysis. World J Urol, 28:117-122. (SCI, 17/73, UROLOGY & NEPHROLOGY).
  38. Jen-Chyan Wang, Chia-Ling Ko, Chun-Cheng Hung, Yu-Chang Tyan, Chern-Hsiung Lai, Wen-Cheng Chen*, Chih-Kuang Wang. Deriving fast setting properties of tetracalcium phosphate/dicalcium phosphate anhydrous bone cement with nanocrystallites on the reactant surfaces. Journal of Dentistry, 38, 158-165. (SCI, 7/83, DENTISTRY, ORAL SURGERY & MEDICINE).
  39. Tze-Wen Chung*, Shyr-Yi Lin, Der-Zen Liu, Yu-Chang Tyan, Juin-Sen Yang. Sustained release of 5-FU from Poloxamer gels interpenetrated by crosslinking chitosan network. Int J Pharm, 382(1-2):39-44. (SCI, 198/261, PHARMACOLOGY & PHARMACY).
  40. Pao-Chi Liao, Yu-Chang Tyan*, Chung-Yao Wang, Jing-Fang Hsu, Tse-Chuan Chou, Hsin-Yi Lin. Assessing the binding selectivity of molecularly imprinted polymer artificial antibodies by mass spectrometry-based profiling system. J Biomed Mater Res, 91A: 597–604. (SCI, 13/79, ENGINEERING, BIOMEDICAL).
  41. Shang-Kwei Wang*, Cheng-Hui Hu, Miao-Chan Lu, Chang-Yih Duh, Pao-Chi Liao, Yu-Chang Tyan. Novel virus-associated proteins encoded by UL112-113 of human cytomegalovirus. J Gen Virol., 90(Pt 12):2840-8. (SCI, 44/160, BIOTECHNOLOGY & APPLIED MICROBIOLOGY).
  42. Ming-Hui Yang, Li-Hua Lo, Yi-Hsuan Chen, Jentaie Shiea*, Pei-Chang Wu, Yu-Chang Tyan, Yuh-Jyh Jong. Study of human neutrophil peptides in saliva by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid Communications in Mass Spectrometry, 23: 3220–3226. (SCI, 19/73, Chemistry analytical).
  43. Shiang-Bin Jong, Shu-Ling Huang, Chang-Shiun Lin, Ming-Hui Yang, Yi-Ling Chen, Ying-Fong Huang, Jentaie Shiea, Ming-Chen Wang, Yu-Chang Tyan*. Evaluation the Effectiveness of 125 I Anti-AFP Monoclonal Antibody on QCM Utilizing Radioactive Measurement. CHEMISTRY , Vol. 67, No. 3, pp. 299-307.
  44. Shu-Ling Huang, Chang-Shiun Lin, Yi-Shan Lu, Shiang-Bin Jong, Ming-Hui Yang, Hsiu-Yu Chang, Yu-Chang Tyan*. α-fetoprotein analysis in human serum through quartz crystal microbalance. IFMBE Proceedings, 25, 116-119. (EI).
  45. Yu-Chang Tyan*, Ming-Hui Yang*, Shiang-Bin Jong, Chih-Kuang Wang, Jentaie Shiea. Melamine contamination. Anal Bioanal Chem, 395:729–735. (SCI, 9/75, CHEMISTRY, ANALYTICAL).
  46. Ming-Hui Yang, Yu-Chang Tyan*. Proteomic approaches for urine biomarker discovery in bladder cancer. Translational Bioinformatics: Bioinformatics of Human Proteomics. Translational Bioinformatics: Bioinformatics of Human Proteomics. Feb, 2013: Volume 3, 2013, pp 309-329.
  47. Ming-Hui Yang, Shiang-Bin Jong, Tze-Wen Chung, Ying-Fong Huang, Yu-Chang Tyan*. Quartz crystal microbalance in clinical application. Biosensors for Health, Environment and Biosecurity. Biosensors for Health, Environment and Biosecurity / Book 2. Jul, 2011: Chapter 11, 257-272.
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